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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Indonesian Journal of Pharmaceutical Science and Technology Prosiding Seminar Biologi INDONESIAN JOURNAL OF PHARMACY Journal of Dentomaxillofacial Science ARSHI Veterinary Letters Jurnal Ilmu dan Teknologi Kayu Tropis JURNAL KAJIAN VETERINER Britain International of Exact Sciences Journal (BIoEx Journal) Jurnal Pusat Inovasi Masyarakat (JPIM)
Vetnizah Juniantito
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary

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Journal : Jurnal Sain Veteriner

 1 
Efek Protektif Andrografolid terhadap Kejadian Kardiotoksisitas Pasca Aplikasi Doksorubisin pada Tikus Sri Wahyuni Salam; Agus Setiyono; Vetnizah Juniantito
Jurnal Sain Veteriner Vol 34, No 2 (2016): Desember
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1133.57 KB) | DOI: 10.22146/jsv.27569

Abstract

Cardiotoxicity is one of the important side effects of doxorubicin, an anthracycline antibiotic and chemotherapeutic drug. The aim of this study was to explore the potential protective effect of andrographolide (Andro), an anti-inflammatory and anti-oxidant agents, against cardiotoxicity induced by doxorubicin (DXR). Thirty Sprague Dawley rats (80-100 g) were divided into four groups: (a) Control (b) DXR (4 mg/kg intraperitoneally (IP) were made weekly for 4 weeks), (c) DXR+Andro20 (low dose andro; 20 mg/kg IP weremade daily for 4 weeks, 24 h after DXR), (d) DXR+Andro100 (high dose andro; 100 mg/kg IP were made daily for 4 weeks, 24 h after DXR). Furthermore, at the end of experimental period, all rats were euthanized and hearts were removed for hispatological analyses. Hematoxylin-eosin (HE) and Masson Trichrome (MT) staining were used to observe the histomorphological alterations and fibrosis of hearts, respectively. Our results showed that andrographolide treatment (20 mg/kg) augmented the detrimental effects of DXR such as decreased body weight and heart weight, as compared with those in DXR-treated rats. Histopathologically, heart tissue from control group showed compact myocardial architecture without any noticeable lesions. Histopathological analysis fromDXR group showed severe inflammation and fibrosis, whereas DXR+Andro20 group showed almost normal heart morphology. Andrographolide at a dosage of 100 mg/kg did not show protective effects against doxorubicin,and even aggravated myocardial inflammation, as compared with DXR-treated rats. These results indicate that low dose of andrographolide compromised doxorubicin-induced decreased body weight, heart inflammation, andfibrosis.
Co-Authors . Jumari . Nafrialdi Agatha Grace Agus Setiyono Aisyah Aisyah Akhmad Endang Zainal Hasan Alfina Zalfa Suryono Andrea Laurentius Antonius Anre Sianturi Arifin Budiman Nugraha Armando Balses Ishimora Bayu Febram Prasetyo Cahyaningsih, Umi D R Agungpriyono Deded Sarip Nawawi Dewi R Agungpriyono Dondhin Sajuthi Dondin Sajuthi Dwi Rofifah Putri Jania Endang Syamsudin Eva Harlina Evy Ayu Arida Evy Damayanthi Fajar Rezandaru Femmi Dwinda Agustini Fivi Melva Diana Gregorius Bhaskara Wikanendra Hanifah Nur Azizah I Nyoman Jaya Wistara IETJE WIENTARSIH Iis Ismawati Indra Hadikrishna Itje Wintarsih Kusmardi Kusmardi L N Sutardi Miranti Fardesiana Putri Mohamad Sadikin Nina Herlina Nopen Meisaroh Nur Indrawaty Lipoeto Putri Ramadhanty Rafida Nisa Maghfiroh Ranady Perwira Nuruzzaman Rimbawan , Rita Kartika Sari Sajuthi, Dondhin Sharon Aurellia Siti Magfiroh Soni Siswanto Sri Estuningsih Sri Wahyuni Salam Sri Widia A Jusman Subangkit, Mawar Syahruddin Said Titta Novianti Vici Eko Handayani Wawaimuli Arozal Wawaimuli Arozal Yenny Rakhmawati